Paxobrook covid tablet

Paxobrook COVID Tablet – Complete Guide

What is Paxobrook COVID Tablet?

Paxobrook COVID Tablet is an oral antiviral medication used for the treatment of mild to moderate COVID-19 in adults and adolescents who are at high risk of developing severe illness. It is a generic version of Paxlovid, originally developed by Pfizer.

Paxobrook is composed of two active ingredients:

• Nirmatrelvir (150 mg) – the primary antiviral compound

• Ritonavir (100 mg) – a booster that enhances the effectiveness of Nirmatrelvir

The tablets are usually packaged together in a combination strip to ensure accurate dosing.

This medicine is not intended for preventive use or for those with severe or critical COVID-19 who are already hospitalized. Instead, it must be used early in the course of infection — ideally within 5 days of symptom onset.

How Does Paxobrook Work?

Paxobrook works through a dual mechanism:

1. Nirmatrelvir targets the 3CL protease enzyme of the SARS-CoV-2 virus. This enzyme is essential for the virus to replicate. By blocking this enzyme, Nirmatrelvir prevents the virus from multiplying, thus slowing the progression of the disease.

2. Ritonavir is not antiviral in this context. Its role is to inhibit liver enzymes (CYP3A4) that would normally break down Nirmatrelvir too quickly. This allows Nirmatrelvir to stay longer in the bloodstream and work more effectively.

The combination works best when started within 5 days of symptoms, reducing the chance of hospitalization or severe disease.

Benefits of Paxobrook COVID Tablet

• ✅ Reduces risk of hospitalization and death in high-risk COVID-19 patients

• ✅ Effective against multiple variants, including Omicron (as per current data)

• ✅ Easy-to-take oral formulation, no need for injections or IV infusions

• ✅ Well-tolerated in most patients with a low risk of serious side effects

• ✅ Approved by global health authorities as part of emergency use strategies (as Paxlovid)

• ✅ Safe for use in adolescents (12 years and older) weighing at least 40 kg

Studies have shown that starting this treatment early can reduce the risk of severe COVID-19 by up to 89%, making it one of the most effective antiviral therapies currently available.

How to Take Paxobrook

Each dose of Paxobrook includes:

• Two 150 mg tablets of Nirmatrelvir

• One 100 mg tablet of Ritonavir

Dosage Instructions:

• Take all three tablets together, twice daily (every 12 hours), for 5 consecutive days

• Swallow tablets whole with water, with or without food

• Complete the full 5-day course even if symptoms improve

Special instructions:

• Start within 5 days of symptom onset

• Do not skip doses

• If a dose is missed and it’s been less than 8 hours, take it immediately

• If more than 8 hours have passed, skip the dose and resume at the next scheduled time

Do not double the next dose to make up for a missed one.

Who Makes Paxobrook?

Paxobrook is manufactured by Healing Pharma India Pvt. Ltd., a well-established Indian pharmaceutical company known for producing generic medicines across therapeutic areas. The company complies with WHO-GMP and Indian regulatory standards, offering cost-effective alternatives to branded medicines.

As a generic version of Paxlovid, Paxobrook is part of India’s contribution to making essential COVID-19 treatments accessible and affordable globally, particularly in low- and middle-income countries.

Is Paxobrook Safe for Humans?

Yes, Paxobrook is considered safe when used under medical supervision for the treatment of COVID-19. It has the same composition and mechanism as Paxlovid, which is authorized for emergency use by global regulatory bodies like:

• US FDA (under Emergency Use Authorization)

• MHRA (UK)

• WHO (included in treatment guidelines)

However, safety depends on the following:

• It is not recommended for people with severe liver or kidney disease unless adjusted appropriately

• Should be used cautiously in people taking medications that interact with Ritonavir, as it affects liver enzymes

• Not intended for children under 12 years or people under 40 kg body weight

Side Effects of Paxobrook

Like all medications, Paxobrook can cause side effects. Most are mild and temporary.

Common Side Effects:

• Altered or bitter taste (dysgeusia)

• Diarrhea

• Headache

• Muscle aches

• Increased blood pressure

Less Common but Important:

• Allergic reactions (rash, itching, swelling)

• Liver enzyme elevations

• Interaction-related effects from other medications

Drug Interactions:

Ritonavir can interact with many medicines, such as:

• Statins

• Blood thinners

• Antiarrhythmics

• Certain antidepressants

• Immunosuppressants

Always inform your doctor about all medications you’re taking before starting Paxobrook.

Disclaimer

This information is intended for educational purposes only and should not be considered a substitute for professional medical advice. Paxobrook should only be taken when prescribed by a qualified healthcare provider after confirming a positive COVID-19 diagnosis and determining eligibility based on medical history and risk factors. Improper use can lead to side effects, resistance, or treatment failure. Always follow your doctor’s instructions and do not self-medicate.